Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age

Author:

Wilkinson Carol L.ORCID,Yankowitz Lisa D.,Chao Jerry Y.ORCID,Gutiérrez Rodrigo,Rhoades Jeff L.ORCID,Shinnar Shlomo,Purdon Patrick L.,Nelson Charles A.

Abstract

AbstractThe development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Developmental changes in periodic peaks include (1) the presence and then absence of a 9-10 Hz alpha peak between 2-6 months, (2) nonlinear changes in high beta peaks (20-30 Hz) between 4-18 months, and (3) the emergence of a low beta peak (12-20 Hz) in some infants after six months of age. We hypothesized that the emergence of the low beta peak may reflect maturation of thalamocortical network development. Infant anesthesia studies observe that GABA-modulating anesthetics do not induce thalamocortical mediated frontal alpha coherence until 10-12 months of age. Using a small cohort of infants (n = 23) with EEG before and during GABA-modulating anesthesia, we provide preliminary evidence that infants with a low beta peak have higher anesthesia-induced alpha coherence compared to those without a low beta peak.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health

U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders

U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences

U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse

JBP Research Network on Toxic Stress

Publisher

Springer Science and Business Media LLC

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