Dominant subtype switch in avian influenza viruses during 2016–2019 in China

Author:

Bi YuhaiORCID,Li JuanORCID,Li Shanqin,Fu Guanghua,Jin TaoORCID,Zhang Cheng,Yang Yongchun,Ma Zhenghai,Tian WenxiaORCID,Li Jida,Xiao Shuqi,Li Liqiang,Yin RenfuORCID,Zhang Yi,Wang Lixin,Qin Yantao,Yao Zhongzi,Meng Fanyu,Hu Dongfang,Li Delong,Wong Gary,Liu Fei,Lv Na,Wang Liang,Fu LifengORCID,Yang Yang,Peng Yun,Ma JinminORCID,Sharshov Kirill,Shestopalov Alexander,Gulyaeva MarinaORCID,Gao George F.ORCID,Chen JianjunORCID,Shi YiORCID,Liu William J.ORCID,Chu Dong,Huang Yu,Liu Yingxia,Liu Lei,Liu Wenjun,Chen Quanjiao,Shi WeifengORCID

Abstract

AbstractWe have surveyed avian influenza virus (AIV) genomes from live poultry markets within China since 2014. Here we present a total of 16,091 samples that were collected from May 2016 to February 2019 in 23 provinces and municipalities in China. We identify 2048 AIV-positive samples and perform next generation sequencing. AIV-positive rates (12.73%) from samples had decreased substantially since 2016, compared to that during 2014–2016 (26.90%). Additionally, H9N2 has replaced H5N6 and H7N9 as the dominant AIV subtype in both chickens and ducks. Notably, novel reassortants and variants continually emerged and disseminated in avian populations, including H7N3, H9N9, H9N6 and H5N6 variants. Importantly, almost all of the H9 AIVs and many H7N9 and H6N2 strains prefer human-type receptors, posing an increased risk for human infections. In summary, our nation-wide surveillance highlights substantial changes in the circulation of AIVs since 2016, which greatly impacts the prevention and control of AIVs in China and worldwide.

Funder

strategic priority research program of the Chinese academy of sciences

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Reference74 articles.

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