Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-017-02258-w.pdf
Reference69 articles.
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3. Maschera, B. et al. Human immunodeficiency virus: Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex. J. Biol. Chem. 271, 33231–33235 (1996).
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