Identification and characterization of two functional variants in the human longevity gene FOXO3-Reference-Cited by-同舟云学术

Identification and characterization of two functional variants in the human longevity gene FOXO3

Published:2017-12 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Flachsbart Friederike,Dose Janina,Gentschew Liljana,Geismann Claudia,Caliebe Amke,Knecht Carolin,Nygaard Marianne,Badarinarayan Nandini,ElSharawy Abdou,May Sandra,Luzius Anne,Torres Guillermo G.,Jentzsch Marlene,Forster Michael,Häsler Robert,Pallauf Kathrin,Lieb Wolfgang,Derbois Céline,Galan Pilar,Drichel Dmitriy,Arlt Alexander^ORCID,Till Andreas^ORCID,Krause-Kyora Ben^ORCID,Rimbach Gerald,Blanché Hélène^ORCID,Deleuze Jean-François,Christiansen Lene,Christensen Kaare,Nothnagel Michael,Rosenstiel Philip,Schreiber Stefan,Franke Andre^ORCID,Sebens Susanne,Nebel Almut

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-017-02183-y.pdf

Reference70 articles.

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3. Nebel, A. et al. A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech. Ageing Dev. 132, 324–330 (2011).

4. Broer, L. et al. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J. Gerontol. A. Biol. Sci. Med. Sci. 70, 110–118 (2015).

5. Willcox, B. J. et al. FOXO3A genotype is strongly associated with human longevity. Proc. Natl Acad. Sci. USA 105, 13987–13992 (2008).

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