Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis

Author:

Bamezai Sharika,Zhang Yapei,Kumari Manisha,Lotfi Mozhgan,Alsaigh TomORCID,Luo LingfengORCID,Kumar Gayatri SureshORCID,Wang Fudi,Ye JianqinORCID,Puri Madhu,Manchanda Romila,Paluri Sesha,Adkar Shaunak S.,Kojima Yoko,Ingelsson Alice,Bell Caitlin F.ORCID,Lopez Nicolas G.,Fu Changhao,Choi Ryan B.ORCID,Miller Zach,Barrios Leo,Walsh Susan,Ahmad Ferhaan,Maegdefessel LarsORCID,Smith Bryan RonainORCID,Leeper Nicholas J.ORCID

Funder

Falk Foundation

American Heart Association

Foundation for the National Institutes of Health

Greathouse Family Foundation

Sarnoff Cardiovascular Research Foundation

Perkin-Elmer Post-doctoral Fellowship

Publisher

Springer Science and Business Media LLC

Reference45 articles.

1. Arnett D. K. et al. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J. Am. Coll. Cardiol. 74, 1376–1414 (2019).

2. Tsao C. W. et al. Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association. Circulation 145, e153-e639 (2022).

3. Ridker, P. M. et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N. Engl. J. Med. 377, 1119–1131 (2017).

4. Adkar, S. S. & Leeper, N. J. Efferocytosis in atherosclerosis. Nat. Rev. Cardiol. https://doi.org/10.1038/s41569-024-01037-7 (2024)

5. Arandjelovic, S. & Ravichandran, K. S. Phagocytosis of apoptotic cells in homeostasis. Nat. Immunol. 16, 907–917 (2015).

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