Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease
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Published:2022-03-21
Issue:1
Volume:13
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Duong Michael TranORCID, Das Sandhitsu R., Lyu Xueying, Xie Long, Richardson Hayley, Xie Sharon X., Yushkevich Paul A., Weiner Michael, Aisen Paul, Petersen Ronald, Jack Clifford R., Jagust William, Trojanowki John Q., Toga Arthur W., Beckett Laurel, Green Robert C., Saykin Andrew J., Morris John C., Shaw Leslie M., Liu Enchi, Montine Tom, Thomas Ronald G., Donohue Michael, Walter Sarah, Gessert Devon, Sather Tamie, Jimenez-Maggiora Gustavo, Harvey Danielle, Bernstein Matthew, Fox Nick, Thompson Paul, Schuff Norbert, DeCarli Charles, Borowski Bret, Gunter Jeff, Senjem Matt, Vemuri Prashanthi, Jones David, Kantarci Kejal, Ward Chad, Koeppe Robert A., Foster Norm, Reiman Eric M., Chen Kewei, Mathis Chet, Landau Susan, Cairns Nigel J., Householder Erin, Taylor-Reinwald Lisa, Lee Virginia M-Y, Korecka Magdalena, Figurski Michal, Crawford Karen, Neu Scott, Foroud Tatiana M., Shen Li, Faber Kelley, Kim Sungeun, Nho Kwangsik, Khachaturian Zaven, Frank Richard, Snyder Peter J., Molchan Susan, Kaye Jeffrey, Quinn Joseph, Lind Betty, Carter Raina, Dolen Sara, Schneider Lon S., Pawluczyk Sonia, Beccera Mauricio, Teodoro Liberty, Spann Bryan M., Brewer James, Vanderswag Helen, Fleisher Adam, Heidebrink Judith L., Lord Joanne L., Mason Sara S., Albers Colleen S., Knopman David, Johnson Kris, Doody Rachelle S., Villanueva-Meyer Javier, Chowdhury Munir, Rountree Susan, Dang Mimi, Stern Yaakov, Honig Lawrence S., Bell Karen L., Ances Beau, Carroll Maria, Leon Sue, Mintun Mark A., Schneider Stacy, Oliver Angela, Griffith Randall, Clark David, Geldmacher David, Brockington John, Roberson Erik, Grossman Hillel, Mitsis Effie, deToledo-Morrell Leyla, Shah Raj C., Duara Ranjan, Varon Daniel, Greig Maria T., Roberts Peggy, Albert Marilyn, Onyike Chiadi, D’Agostino Daniel, Kielb Stephanie, Galvin James E., Pogorelec Dana M., Cerbone Brittany, Michel Christina A., Rusinek Henry, de Leon Mony J., Glodzik Lidia, De Santi Susan, Doraiswamy P. Murali, Petrella Jeffrey R., Wong Terence Z., Clark Christopher M., Arnold Steven E., Karlawish Jason H., Wolk David A., Smith Charles D., Jicha Gregory, Hardy Peter, Sinha Partha, Oates Elizabeth, Conrad Gary, Lopez Oscar L., Oakley MaryAnn, Simpson Donna M., Porsteinsson Anton P., Goldstein Bonnie S., Martin Kim, Makino Kelly M., Ismail M. Saleem, Brand Connie, Mulnard Ruth A., Thai Gaby, McAdams-Ortiz Catherine, Womack Kyle, Mathews Dana, Quiceno Mary, Diaz-Arrastia Ramon, King Richard, Weiner Myron, Cook Kristen Martin, Devous Michael, Levey Allan I., Lah James J., Cellar Janet S., Burns Jeffrey M., Anderson Heather S., Swerdlow Russell H., Apostolova Liana, Tingus Kathleen, Woo Ellen, Silverman Daniel H. S., Lu Po H., Bartzokis George, Graff-Radford Neill R., Parfitt Francine, Kendall Tracy, Johnson Heather, Farlow Martin R., Hake Ann Marie, Matthews Brandy R., Herring Scott, Hunt Cynthia, van Dyck Christopher H., Carson Richard E., MacAvoy Martha G., Chertkow Howard, Bergman Howard, Hosein Chris, Black Sandra, Stefanovic Bojana, Caldwell Curtis, Hsiung Ging-Yuek Robin, Feldman Howard, Mudge Benita, Assaly Michele, Kertesz Andrew, Rogers John, Bernick Charles, Munic Donna, Kerwin Diana, Mesulam Marek Marsel, Lipowski Kristine, Wu Chuang-Kuo, Johnson Nancy, Sadowsky Carl, Martinez Walter, Villena Teresa, Turner Raymond Scott, Johnson Kathleen, Reynolds Brigid, Sperling Reisa A., Johnson Keith A., Marshall Gad, Frey Meghan, Yesavage Jerome, Taylor Joy L., Lane Barton, Rosen Allyson, Tinklenberg Jared, Sabbagh Marwan N., Belden Christine M., Jacobson Sandra A., Sirrel Sherye A., Kowall Neil, Killiany Ronald, Budson Andrew E., Norbash Alexander, Johnson Patricia Lynn, Obisesan Thomas O., Wolday Saba, Allard Joanne, Lerner Alan, Ogrocki Paula, Hudson Leon, Fletcher Evan, Carmichael Owen, Olichney John, Kittur Smita, Borrie Michael, Lee T.-Y., Bartha Rob, Johnson Sterling, Asthana Sanjay, Carlsson Cynthia M., Potkin Steven G., Preda Adrian, Nguyen Dana, Tariot Pierre, Reeder Stephanie, Bates Vernice, Capote Horacio, Rainka Michelle, Scharre Douglas W., Kataki Maria, Adeli Anahita, Zimmerman Earl A., Celmins Dzintra, Brown Alice D., Pearlson Godfrey D., Blank Karen, Anderson Karen, Santulli Robert B., Kitzmiller Tamar J., Schwartz Eben S., Sink Kaycee M., Williamson Jeff D., Garg Pradeep, Watkins Franklin, Ott Brian R., Querfurth Henry, Tremont Geoffrey, Salloway Stephen, Malloy Paul, Correia Stephen, Rosen Howard J., Miller Bruce L., Mintzer Jacobo, Spicer Kenneth, Bachman David, Finger Elizabether, Pasternak Stephen, Rachinsky Irina, Drost Dick, Pomara Nunzio, Hernando Raymundo, Sarrael Antero, Schultz Susan K., Boles Ponto Laura L., Shim Hyungsub, Smith Karen Ekstam, Relkin Norman, Chiang Gloria, Ravdin Lisa, Smith Amanda, Fargher Kristin, Raj Balebail Ashok, Wolk David A., Nasrallah Ilya M.ORCID,
Abstract
AbstractAlzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected relative to T and displayed better cognition than the canonical group. Groups susceptible to T had more hypometabolism than expected given T and exhibited worse cognitive decline, with imaging and clinical measures concordant with non-AD copathologies. Together, T/NM mismatch reveals distinct imaging signatures with pathobiological and prognostic implications for AD.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference73 articles.
1. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiat 64, 146–148 (1907). 2. Fischer, O. Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmässige Veränderung der Hirnrinde bei seniler Demenz. Monatsschr Psychiat Neurol. 22, 361–372 (1907). 3. Jack, C. R. et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 14, 535–562 (2018). 4. De Strooper, B. & Karran, E. The cellular phase of Alzheimer’s disease. Cell 164, 603–615 (2006). 5. Jack, C. R. et al. Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia. JAMA Neurol. 321, 2316–2325 (2019).
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