Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-04203-x.pdf
Reference80 articles.
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2. DePristo, M. A., Weinreich, D. M. & Hartl, D. L. Missense meanderings in sequence space: a biophysical view of protein evolution. Nat. Rev. Genet. 6, 678–687 (2005).
3. Zeldovich, K. B., Chen, P. & Shakhnovich, E. I. Protein stability imposes limits on organism complexity and speed of molecular evolution. Proc. Natl Acad. Sci. USA 104, 16152–16157 (2007).
4. Gong, L. I., Suchard, M. A. & Bloom, J. D. Stability-mediated epistasis constrains the evolution of an influenza protein. eLife 2, e00631 (2013).
5. Hartl, F. U., Bracher, A. & Hayer-Hartl, M. Molecular chaperones in protein folding and proteostasis. Nature 475, 324–332 (2011).
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