Cross-species spill-over potential of the H9N2 bat influenza A virus
-
Published:2024-04-25
Issue:1
Volume:15
Page:
-
ISSN:2041-1723
-
Container-title:Nature Communications
-
language:en
-
Short-container-title:Nat Commun
Author:
El-Shesheny RabehORCID, Franks John, Kandeil AhmedORCID, Badra RebeccaORCID, Turner JasmineORCID, Seiler Patrick, Marathe Bindumadhav M., Jeevan Trushar, Kercher LisaORCID, Hu Meng, Sim Yul EumORCID, Hui Kenrie P. Y.ORCID, Chan Michael C. W.ORCID, Thompson Andrew J., McKenzie Pamela, Govorkova Elena A.ORCID, Russell Charles J.ORCID, Vogel PeterORCID, Paulson James C.ORCID, Peiris J. S. MalikORCID, Webster Robert G., Ali Mohamed A., Kayali GhaziORCID, Webby Richard J.ORCID
Abstract
AbstractIn 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus–like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases
Publisher
Springer Science and Business Media LLC
Reference42 articles.
1. Tong, S. et al. A distinct lineage of influenza A virus from bats. Proc. Natl Acad. Sci. USA 109, 4269–4274 (2012). 2. Ciminski, K., Pfaff, F., Beer, M. & Schwemmle, M. Bats reveal the true power of influenza A virus adaptability. PLoS Pathog. 16, e1008384 (2020). 3. Kandeil, A. et al. Isolation and characterization of a distinct influenza A virus from Egyptian bats. J. Virol. 93, e01059-18 (2019). 4. Calisher, C. H., Childs, J. E., Field, H. E., Holmes, K. V. & Schountz, T. Bats: important reservoir hosts of emerging viruses. Clin. Microbiol. Rev. 19, 531–545 (2006). 5. Li, J., Lai, S., Gao, G. F. & Shi, W. The emergence, genomic diversity and global spread of SARS-CoV−2. Nature 600, 408–418 (2021).
|
|