Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
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Published:2020-10-06
Issue:1
Volume:11
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Burn EdwardORCID, You Seng ChanORCID, Sena Anthony G., Kostka KristinORCID, Abedtash HamedORCID, Abrahão Maria Tereza F.ORCID, Alberga Amanda, Alghoul HebaORCID, Alser OsaidORCID, Alshammari Thamir M., Aragon Maria, Areia CarlosORCID, Banda Juan M.ORCID, Cho Jaehyeong, Culhane Aedin C.ORCID, Davydov Alexander, DeFalco Frank J., Duarte-Salles Talita, DuVall Scott, Falconer Thomas, Fernandez-Bertolin Sergio, Gao Weihua, Golozar AsiehORCID, Hardin Jill, Hripcsak George, Huser Vojtech, Jeon HokyunORCID, Jing Yonghua, Jung Chi Young, Kaas-Hansen Benjamin SkovORCID, Kaduk Denys, Kent Seamus, Kim YeesukORCID, Kolovos Spyros, Lane Jennifer C. E.ORCID, Lee Hyejin, Lynch Kristine E., Makadia Rupa, Matheny Michael E., Mehta Paras P.ORCID, Morales Daniel R., Natarajan KarthikORCID, Nyberg FredrikORCID, Ostropolets Anna, Park Rae Woong, Park JimyungORCID, Posada Jose D.ORCID, Prats-Uribe AlbertORCID, Rao Gowtham, Reich Christian, Rho Yeunsook, Rijnbeek Peter, Schilling Lisa M., Schuemie Martijn, Shah Nigam H.ORCID, Shoaibi Azza, Song SeokyoungORCID, Spotnitz Matthew, Suchard Marc A.ORCID, Swerdel Joel N., Vizcaya DavidORCID, Volpe Salvatore, Wen Haini, Williams Andrew E.ORCID, Yimer Belay B.ORCID, Zhang LinORCID, Zhuk Oleg, Prieto-Alhambra DanielORCID, Ryan Patrick
Abstract
AbstractComorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.
Funder
Innovative Medicines Initiative
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference28 articles.
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