Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
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Published:2020-01-30
Issue:1
Volume:11
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Papadimitriou Nikos, Dimou Niki, Tsilidis Konstantinos K.ORCID, Banbury Barbara, Martin Richard M.ORCID, Lewis Sarah J.ORCID, Kazmi Nabila, Robinson Timothy M., Albanes Demetrius, Aleksandrova Krasimira, Berndt Sonja I., Timothy Bishop D.ORCID, Brenner Hermann, Buchanan Daniel D.ORCID, Bueno-de-Mesquita Bas, Campbell Peter T., Castellví-Bel Sergi, Chan Andrew T.ORCID, Chang-Claude Jenny, Ellingjord-Dale Merete, Figueiredo Jane C., Gallinger Steven J., Giles Graham G.ORCID, Giovannucci Edward, Gruber Stephen B., Gsur AndreaORCID, Hampe JochenORCID, Hampel HeatherORCID, Harlid SophiaORCID, Harrison Tabitha A.ORCID, Hoffmeister Michael, Hopper John L., Hsu Li, María Huerta JoséORCID, Huyghe Jeroen R.ORCID, Jenkins Mark A.ORCID, Keku Temitope O., Kühn Tilman, La Vecchia CarloORCID, Le Marchand Loic, Li Christopher I., Li Li, Lindblom Annika, Lindor Noralane M., Lynch Brigid, Markowitz Sanford D., Masala GiovannaORCID, May Anne M., Milne RogerORCID, Monninkhof Evelyn, Moreno Lorena, Moreno VictorORCID, Newcomb Polly A.ORCID, Offit Kenneth, Perduca VittorioORCID, Pharoah Paul D. P.ORCID, Platz Elizabeth A., Potter John D.ORCID, Rennert GadORCID, Riboli Elio, Sánchez Maria-Jose, Schmit Stephanie L.ORCID, Schoen Robert E.ORCID, Severi Gianluca, Sieri Sabina, Slattery Martha L., Song Mingyang, Tangen Catherine M., Thibodeau Stephen N., Travis Ruth C., Trichopoulou Antonia, Ulrich Cornelia M., van Duijnhoven Franzel J. B., Van Guelpen BethanyORCID, Vodicka Pavel, White Emily, Wolk AlicjaORCID, Woods Michael O., Wu Anna H., Peters UlrikeORCID, Gunter Marc J., Murphy NeilORCID
Abstract
AbstractPhysical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
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