Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
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Published:2017-10-13
Issue:1
Volume:8
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Joshi Peter K.ORCID, Pirastu NicolaORCID, Kentistou Katherine A., Fischer Krista, Hofer Edith, Schraut Katharina E., Clark David W., Nutile Teresa, Barnes Catriona L. K., Timmers Paul R. H. J., Shen XiaORCID, Gandin Ilaria, McDaid Aaron F.ORCID, Hansen Thomas FolkmannORCID, Gordon Scott D., Giulianini Franco, Boutin Thibaud S., Abdellaoui Abdel, Zhao Wei, Medina-Gomez CarolinaORCID, Bartz Traci M., Trompet Stella, Lange Leslie A., Raffield Laura, van der Spek Ashley, Galesloot Tessel E., Proitsi Petroula, Yanek Lisa R.ORCID, Bielak Lawrence F., Payton Antony, Murgia FedericoORCID, Concas Maria Pina, Biino GinevraORCID, Tajuddin Salman M.ORCID, Seppälä IlkkaORCID, Amin Najaf, Boerwinkle Eric, Børglum Anders D., Campbell Archie, Demerath Ellen W., Demuth Ilja, Faul Jessica D., Ford Ian, Gialluisi AlessandroORCID, Gögele Martin, Graff MariaElisa, Hingorani Aroon, Hottenga Jouke-Jan, Hougaard David M.ORCID, Hurme Mikko A., Ikram M. ArfanORCID, Jylhä Marja, Kuh Diana, Ligthart Lannie, Lill Christina M.ORCID, Lindenberger Ulman, Lumley Thomas, Mägi Reedik, Marques-Vidal PedroORCID, Medland Sarah E.ORCID, Milani LiliORCID, Nagy Reka, Ollier William E. R., Peyser Patricia A., Pramstaller Peter P., Ridker Paul M., Rivadeneira FernandoORCID, Ruggiero Daniela, Saba Yasaman, Schmidt Reinhold, Schmidt Helena, Slagboom P. Eline, Smith Blair H.ORCID, Smith Jennifer A.ORCID, Sotoodehnia Nona, Steinhagen-Thiessen Elisabeth, van Rooij Frank J. A., Verbeek André L., Vermeulen Sita H., Vollenweider Peter, Wang Yunpeng, Werge Thomas, Whitfield John B.ORCID, Zonderman Alan B., Lehtimäki Terho, Evans Michele K., Pirastu Mario, Fuchsberger Christian, Bertram Lars, Pendleton NeilORCID, Kardia Sharon L. R., Ciullo Marina, Becker Diane M., Wong AndrewORCID, Psaty Bruce M., van Duijn Cornelia M., Wilson James G., Jukema J. WouterORCID, Kiemeney Lambertus, Uitterlinden André G., Franceschini Nora, North Kari E., Weir David R., Metspalu Andres, Boomsma Dorret I., Hayward CarolineORCID, Chasman Daniel, Martin Nicholas G., Sattar Naveed, Campbell Harry, Esko Tōnu, Kutalik Zoltán, Wilson James F.ORCID
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference53 articles.
1. Herskind, A. M. et al. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 97, 319–323 (1996). 2. Deelen, J. et al. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10, 686–698 (2011). 3. Broer, L. et al. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy. J. Gerontol. A Biol. Sci. Med. Sci. 70, 110–118 (2015). 4. Joshi, P. K. et al. Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan. Nat. Commun. 7, 11174 (2016). 5. Pilling, L. C. et al. Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging 8, 547–560 (2016).
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