Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

Author:

Cope Elise C.,Wang Samantha H.,Waters Renée C.,Gore Isha R.,Vasquez Betsy,Laham Blake J.,Gould ElizabethORCID

Abstract

AbstractMutation or deletion of theSHANK3gene, which encodes a synaptic scaffolding protein, is linked to autism spectrum disorder and Phelan-McDermid syndrome, conditions associated with social memory impairments.Shank3Bknockout mice also exhibit social memory deficits. The CA2 region of the hippocampus integrates numerous inputs and sends a major output to the ventral CA1 (vCA1). Despite finding few differences in excitatory afferents to the CA2 inShank3Bknockout mice, we found that activation of CA2 neurons as well as the CA2-vCA1 pathway restored social recognition function to wildtype levels. vCA1 neuronal oscillations have been linked to social memory, but we observed no differences in these measures between wildtype andShank3Bknockout mice. However, activation of the CA2 enhanced vCA1 theta power inShank3Bknockout mice, concurrent with behavioral improvements. These findings suggest that stimulating adult circuitry in a mouse model with neurodevelopmental impairments can invoke latent social memory function.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

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