A structural mechanism for directing corepressor-selective inverse agonism of PPARγ-Reference-Cited by-同舟云学术

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Published:2018-11-08 Issue:1 Volume:9 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Brust Richard^ORCID,Shang Jinsai^ORCID,Fuhrmann Jakob,Mosure Sarah A.,Bass Jared,Cano Andrew,Heidari Zahra,Chrisman Ian M.,Nemetchek Michelle D.,Blayo Anne-Laure,Griffin Patrick R.,Kamenecka Theodore M.,Hughes Travis S.,Kojetin Douglas J.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-018-07133-w.pdf

Reference69 articles.

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3. Choi, J. H. et al. Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated phosphorylation. Nature 477, 477–481 (2011).

4. Choi, S. S. et al. A novel non-agonist peroxisome proliferator-activated receptor gamma (PPARgamma) ligand UHC1 blocks PPARgamma phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity. J. Biol. Chem. 289, 26618–26629 (2014).

5. Stechschulte, L. A. et al. PPARG post-translational modifications regulate bone formation and bone resorption. EBioMedicine 10, 174–184 (2016).

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