Sign epistasis caused by hierarchy within signalling cascades
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-03644-8.pdf
Reference29 articles.
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3. Weinreich, D. M., Delaney, N. F., DePristo, M. A. & Hartl, D. L. Darwinian evolution can follow only very few mutational paths to fitter proteins. Science 312, 111–114 (2006).
4. Podgornaia, A. I. & Laub, M. T. Pervasive degeneracy and epistasis in a protein–protein interface. Science 347, 673–677 (2015).
5. Kvitek, D. J. & Sherlock, G. Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape. PLoS Genet. 7, e1002056 (2011).
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