Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
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Published:2021-08-24
Issue:1
Volume:12
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Everson Todd M.ORCID, Vives-Usano Marta, Seyve Emie, Cardenas Andres, Lacasaña MarinaORCID, Craig Jeffrey M., Lesseur CorinaORCID, Baker Emily R., Fernandez-Jimenez NoraORCID, Heude BarbaraORCID, Perron Patrice, Gónzalez-Alzaga Beatriz, Halliday Jane, Deyssenroth Maya A., Karagas Margaret R., Íñiguez Carmen, Bouchard Luigi, Carmona-Sáez PedroORCID, Loke Yuk J., Hao KeORCID, Belmonte ThaliaORCID, Charles Marie A., Martorell-Marugán JordiORCID, Muggli EvelyneORCID, Chen Jia, Fernández Mariana F.ORCID, Tost JorgORCID, Gómez-Martín AntonioORCID, London Stephanie J.ORCID, Sunyer Jordi, Marsit Carmen J.ORCID, Lepeule JohannaORCID, Hivert Marie-France, Bustamante MarionaORCID
Abstract
AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference82 articles.
1. Curtin, S. C. & Mathews, T. J. Smoking prevalence and cessation before and during pregnancy: data from the birth certificate, 2014. Natl. Vital Stat. Reports 65, 1–14 (2016). 2. Smedberg, J., Lupattelli, A., Mårdby, A.-C. & Nordeng, H. Characteristics of women who continue smoking during pregnancy: a cross-sectional study of pregnant women and new mothers in 15 European countries. BMC Pregnancy Childbirth 14, 213 (2014). 3. National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. https://pubmed.ncbi.nlm.nih.gov/24455788/ (Reports of the Surgeon General, 2014). 4. Jauniaux, E. & Burton, G. J. Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit. Early Hum. Dev. 83, 699–706 (2007). 5. Zdravkovic, T., Genbacev, O., Mcmaster, M. T. & Fisher, S. J. The adverse effects of maternal smoking on the human. Placenta 26, S81–S86 (2005).
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