Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Author:

Geyer Felipe C.,Li Anqi,Papanastasiou Anastasios D.,Smith Alison,Selenica Pier,Burke Kathleen A.,Edelweiss Marcia,Wen Huei-Chi,Piscuoglio SalvatoreORCID,Schultheis Anne M.,Martelotto Luciano G.,Pareja Fresia,Kumar Rahul,Brandes Alissa,Fan Dan,Basili Thais,Da Cruz Paula Arnaud,Lozada John R.ORCID,Blecua Pedro,Muenst Simone,Jungbluth Achim A.,Foschini Maria P.,Wen Hannah Y.,Brogi Edi,Palazzo Juan,Rubin Brian P.,Ng Charlotte K. Y.ORCID,Norton Larry,Varga Zsuzsanna,Ellis Ian O.,Rakha Emad A.,Chandarlapaty SaratORCID,Weigelt Britta,Reis-Filho Jorge S.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Reference69 articles.

1. Hayes, M. M. Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation. J. Clin. Pathol. 64, 477–484 (2011).

2. Lakhani, S. R., Ellis, I. O., Schnitt, S. J., Tan, P. H. & van de Vijver, M. J. WHO Classification of Tumours of the Breast (IARC, Lyon, 2012).

3. Nadelman, C. M., Leslie, K. O. & Fishbein, M. C. “Benign,” metastasizing adenomyoepithelioma of the breast: a report of 2 cases. Arch. Pathol. Lab. Med. 130, 1349–1353 (2006).

4. Moritz, A. W., Wiedenhoefer, J. F., Profit, A. P. & Jagirdar, J. Breast adenomyoepithelioma and adenomyoepithelioma with carcinoma (malignant adenomyoepithelioma) with associated breast malignancies: a case series emphasizing histologic, radiologic, and clinical correlation. Breast 29, 132–139 (2016).

5. Ng, C. K., Schultheis, A. M., Bidard, F. C., Weigelt, B. & Reis-Filho, J. S. Breast cancer genomics from microarrays to massively parallel sequencing: paradigms and new insights. J. Natl. Cancer Inst. 107, djv015 (2015). pii.

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