Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection-Reference-Cited by-同舟云学术

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Published:2022-08-10 Issue:1 Volume:13 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Khan Khadija^ORCID,Karim Farina,Ganga Yashica,Bernstein Mallory^ORCID,Jule Zesuliwe,Reedoy Kajal,Cele Sandile,Lustig Gila,Amoako Daniel^ORCID,Wolter Nicole^ORCID,Samsunder Natasha,Sivro Aida^ORCID,San James Emmanuel^ORCID,Giandhari Jennifer,Tegally Houriiyah,Pillay Sureshnee,Naidoo Yeshnee,Mazibuko Matilda,Miya Yoliswa,Ngcobo Nokuthula,Manickchund Nithendra,Magula Nombulelo,Karim Quarraisha Abdool^ORCID,von Gottberg Anne^ORCID,Abdool Karim Salim S.^ORCID,Hanekom Willem,Gosnell Bernadett I.^ORCID,Khoza Thandeka,Smit Theresa,Wong Emily,Lessells Richard J.,de Oliveira Tulio,Moosa Mahomed-Yunus S.^ORCID,Sigal Alex^ORCID,

Abstract

AbstractSARS-CoV-2 Omicron (B.1.1.529) BA.4 and BA.5 sub-lineages, first detected in South Africa, have changes relative to Omicron BA.1 including substitutions in the spike receptor binding domain. Here we isolated live BA.4 and BA.5 viruses and measured BA.4/BA.5 neutralization elicited by BA.1 infection either in the absence or presence of previous vaccination as well as from vaccination without BA.1 infection. In BA.1-infected unvaccinated individuals, neutralization relative to BA.1 declines 7.6-fold for BA.4 and 7.5-fold for BA.5. In vaccinated individuals with subsequent BA.1 infection, neutralization relative to BA.1 decreases 3.2-fold for BA.4 and 2.6-fold for BA.5. The fold-drop versus ancestral virus neutralization in this group is 4.0-fold for BA.1, 12.9-fold for BA.4, and 10.3-fold for BA.5. In contrast, BA.4/BA.5 escape is similar to BA.1 in the absence of BA.1 elicited immunity: fold-drop relative to ancestral virus neutralization is 19.8-fold for BA.1, 19.6-fold for BA.4, and 20.9-fold for BA.5. These results show considerable escape of BA.4/BA.5 from BA.1 elicited immunity which is moderated with vaccination and may indicate that BA.4/BA.5 may have the strongest selective advantage in evading neutralization relative to BA.1 in unvaccinated, BA.1 infected individuals.

Funder

Bill and Melinda Gates Foundation

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

Link

https://www.nature.com/articles/s41467-022-32396-9.pdf

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