Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating
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Published:2024-02-06
Issue:1
Volume:15
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Zhu YangORCID, Deng Kaicheng, Zhou Jianwei, Lai Chong, Ma Zuwei, Zhang Hua, Pan Jiazhen, Shen Liyin, Bucknor Matthew D., Ozhinsky EugeneORCID, Kim SeungilORCID, Chen Guangjie, Ye Sang-ho, Zhang Yue, Liu Donghong, Gao ChangyouORCID, Xu Yonghua, Wang Huanan, Wagner William R.ORCID
Abstract
AbstractShape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.
Funder
Ministry of Science and Technology of the People’s Republic of China National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference39 articles.
1. Lendlein, A. & Gould, O. E. C. Reprogrammable recovery and actuation behaviour of shape-memory polymers. Nat. Rev. Mater. 4, 116–133 (2019). 2. Lendlein, A. & Kelch, S. Shape-memory polymers. Angew. Chem. Int. Ed. 41, 2034–2057 (2002). 3. Hu, J., Zhu, Y., Huang, H. & Lu, J. Recent advances in shape–memory polymers: Structure, mechanism, functionality, modeling and applications. Prog. Polym. Sci. 37, 1720–1763 (2012). 4. Delaey, J., Dubruel, P. & Van Vlierberghe, S. Shape‐memory polymers for biomedical applications. Adv. Funct. Mater. 30, 1909047 (2020). 5. Zhao, W., Liu, L., Zhang, F., Leng, J. & Liu, Y. Shape memory polymers and their composites in biomedical applications. Mater. Sci. Eng. C. 97, 864–883 (2019).
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