Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cells
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41467-024-51695-x.pdf
Reference67 articles.
1. Makarova, K. S. et al. Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants. Nat. Rev. Microbiol. 18, 67–83 (2020).
2. Hille, F. et al. The biology of CRISPR-Cas: backward and forward. Cell 172, 1239–1259 (2018).
3. Xiao, Y. et al. Structure basis for directional R-loop formation and substrate handover mechanisms in Type I CRISPR-Cas system. Cell 170, 48–60.e11 (2017).
4. Cheng, F. et al. Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon. J. Genet. Genomics 44, 541–548 (2017).
5. Luo, M. L., Mullis, A. S., Leenay, R. T. & Beisel, C. L. Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression. Nucleic Acids Res. 43, 674–681 (2015).
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