LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-03943-0.pdf
Reference66 articles.
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3. Vudattu, N. K. & Herold, K. C. Treatment of new onset type 1 diabetes with teplizumab: successes and pitfalls in development. Expert. Opin. Biol. Ther. 14, 377–385 (2014).
4. Moran, A. et al. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet 381, 1905–1915 (2013).
5. Sherry, N. A. et al. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 55, 3238–3245 (2006).
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