PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
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Published:2018-07-25
Issue:1
Volume:9
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
van Setten JessicaORCID, Brody Jennifer A.ORCID, Jamshidi Yalda, Swenson Brenton R., Butler Anne M., Campbell Harry, Del Greco Fabiola M., Evans Daniel S., Gibson Quince, Gudbjartsson Daniel F., Kerr Kathleen F.ORCID, Krijthe Bouwe P., Lyytikäinen Leo-PekkaORCID, Müller Christian, Müller-Nurasyid MartinaORCID, Nolte Ilja M.ORCID, Padmanabhan Sandosh, Ritchie Marylyn D.ORCID, Robino Antonietta, Smith Albert V.ORCID, Steri MaristellaORCID, Tanaka Toshiko, Teumer AlexanderORCID, Trompet Stella, Ulivi Sheila, Verweij NiekORCID, Yin Xiaoyan, Arnar David O., Asselbergs Folkert W.ORCID, Bader Joel S.ORCID, Barnard John, Bis Josh, Blankenberg Stefan, Boerwinkle Eric, Bradford Yuki, Buckley Brendan M., Chung Mina K., Crawford Dana, den Hoed Marcel, Denny Josh C., Dominiczak Anna F.ORCID, Ehret Georg B.ORCID, Eijgelsheim Mark, Ellinor Patrick T.ORCID, Felix Stephan B., Franco Oscar H., Franke LudeORCID, Harris Tamara B., Holm Hilma, Ilaria Gandin, Iorio Annamaria, Kähönen Mika, Kolcic Ivana, Kors Jan A., Lakatta Edward G., Launer Lenore J., Lin HonghuangORCID, Lin Henry J., Loos Ruth J. F.ORCID, Lubitz Steven A., Macfarlane Peter W., Magnani Jared W., Leach Irene Mateo, Meitinger Thomas, Mitchell Braxton D., Munzel ThomasORCID, Papanicolaou George J., Peters Annette, Pfeufer Arne, Pramstaller Peter P., Raitakari Olli T., Rotter Jerome I., Rudan IgorORCID, Samani Nilesh J., Schlessinger David, Silva Aldana Claudia T., Sinner Moritz F., Smith Jonathan D.ORCID, Snieder Harold, Soliman Elsayed Z.ORCID, Spector Timothy D., Stott David J., Strauch Konstantin, Tarasov Kirill V.ORCID, Thorsteinsdottir Unnur, Uitterlinden Andre G., Van Wagoner David R.ORCID, Völker Uwe, Völzke Henry, Waldenberger Melanie, Jan Westra HarmORCID, Wild Philipp S., Zeller Tanja, Alonso AlvaroORCID, Avery Christy L., Bandinelli Stefania, Benjamin Emelia J.ORCID, Cucca FrancescoORCID, Dörr Marcus, Ferrucci Luigi, Gasparini Paolo, Gudnason Vilmundur, Hayward CarolineORCID, Heckbert Susan R., Hicks Andrew A.ORCID, Jukema J. WouterORCID, Kääb Stefan, Lehtimäki Terho, Liu Yongmei, Munroe Patricia B.ORCID, Parsa Afshin, Polasek Ozren, Psaty Bruce M., Roden Dan M., Schnabel Renate B., Sinagra GianfrancoORCID, Stefansson Kari, Stricker Bruno H., van der Harst PimORCID, van Duijn Cornelia M., Wilson James F.ORCID, Gharib Sina A., de Bakker Paul I. W., Isaacs AaronORCID, Arking Dan E., Sotoodehnia Nona
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference35 articles.
1. Kannel, W. B. & Benjamin, E. J. Current perceptions of the epidemiology of atrial fibrillation. Cardiol. Clin. 27, 13–24 (2009). 2. Hanson, B. et al. Genetic factors in the electrocardiogram and heart rate of twins reared apart and together. Am. J. Cardiol. 63, 606–609 (1989). 3. Pfeufer, A. et al. Genome-wide association study of PR interval. Nat. Genet. 42, 153–159 (2010). 4. Holm, H. et al. Several common variants modulate heart rate, PR interval and QRS duration. Nat. Genet. 42, 117–122 (2010). 5. Bulik-Sullivan, B. K. et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291–295 (2015).
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