∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling-Reference-Cited by-同舟云学术

∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling

Published:2018-01-17 Issue:1 Volume:9 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Campbell Hamish,Fleming Nicholas,Roth Imogen,Mehta Sunali,Wiles Anna,Williams Gail,Vennin Claire,Arsic Nikola,Parkin Ashleigh,Pajic Marina,Munro Fran,McNoe Les,Black Michael,McCall John,Slatter Tania L.,Timpson Paul,Reddel Roger^ORCID,Roux Pierre,Print Cristin,Baird Margaret A.,Braithwaite Antony W.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-017-02408-0.pdf

Reference62 articles.

1. Bourdon, J. C. et al. p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19, 2122–2137 (2005).

2. Flaman, J.-M. et al. The human tumour suppressor gene p53 is alternatively spliced in normal cells. Oncogene 12, 813–818 (1996).

3. Hofstetter, G. et al. The N-terminally truncated p53 isoform Δ40p53 influences prognosis in mucinous ovarian cancer. Int. J. Gynecol. Cancer 22, 372–379 (2012).

4. Senturk, S. et al. p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc. Natl Acad. Sci. USA 111, E3287–E3296 (2014).

5. Marcel, V. et al. Delta160p53 is a novel N-terminal p53 isoform encoded by Delta133p53 transcript. FEBS Lett. 584, 4463–4468 (2010).

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