∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-017-02408-0.pdf
Reference62 articles.
1. Bourdon, J. C. et al. p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19, 2122–2137 (2005).
2. Flaman, J.-M. et al. The human tumour suppressor gene p53 is alternatively spliced in normal cells. Oncogene 12, 813–818 (1996).
3. Hofstetter, G. et al. The N-terminally truncated p53 isoform Δ40p53 influences prognosis in mucinous ovarian cancer. Int. J. Gynecol. Cancer 22, 372–379 (2012).
4. Senturk, S. et al. p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc. Natl Acad. Sci. USA 111, E3287–E3296 (2014).
5. Marcel, V. et al. Delta160p53 is a novel N-terminal p53 isoform encoded by Delta133p53 transcript. FEBS Lett. 584, 4463–4468 (2010).
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