Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
Author:
Funder
HHMI (DRL) and CRI
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-05834-w.pdf
Reference32 articles.
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3. Singer, A. New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 14, 207–215 (2002).
4. Egawa, T. & Littman, D. R. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat. Immunol. 9, 1131–1139 (2008).
5. Etzensperger, R. et al. Identification of lineage-specifying cytokines that signal all CD8(+)-cytotoxic-lineage-fate ‘decisions’ in the thymus. Nat. Immunol. 18, 1218–1227 (2017).
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