Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-04238-0.pdf
Reference35 articles.
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2. Rosenberg, R. N., Lambracht-Washington, D., Yu, G. & Xia, W. Genomics of Alzheimer disease: a review. JAMA Neurol. 73, 867–874 (2016).
3. Jonsson, T. et al. A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline. Nature 488, 96–99 (2012).
4. Kokawa, A. et al. The A673T mutation in the amyloid precursor protein reduces the production of beta-amyloid protein from its beta-carboxyl terminal fragment in cells. Acta Neuropathol. Commun. 3, 66 (2015).
5. Ting, S. K. et al. Absence of A673T amyloid-beta precursor protein variant in Alzheimer’s disease and other neurological diseases. Neurobiol. Aging 34, 2441.e2447–2448 (2013).
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