Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
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Published:2019-08-13
Issue:1
Volume:10
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Wang HemingORCID, Lane Jacqueline M., Jones Samuel E.ORCID, Dashti Hassan S.ORCID, Ollila Hanna M., Wood Andrew R., van Hees Vincent T.ORCID, Brumpton BenORCID, Winsvold Bendik S.ORCID, Kantojärvi Katri, Palviainen TeemuORCID, Cade Brian E., Sofer TamarORCID, Song YanweiORCID, Patel Krunal, Anderson Simon G.ORCID, Bechtold David A.ORCID, Bowden Jack, Emsley Richard, Kyle Simon D., Little Max A., Loudon Andrew S., Scheer Frank A. J. L.ORCID, Purcell Shaun M., Richmond Rebecca C.ORCID, Spiegelhalder Kai, Tyrrell JessicaORCID, Zhu Xiaofeng, Hublin Christer, Kaprio Jaakko A.ORCID, Kristiansson KatiORCID, Sulkava Sonja, Paunio Tiina, Hveem Kristian, Nielsen Jonas B., Willer Cristen J.ORCID, Zwart John-Anker, Strand Linn B., Frayling Timothy M., Ray David, Lawlor Deborah A.ORCID, Rutter Martin K., Weedon Michael N., Redline Susan, Saxena RichaORCID
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference71 articles.
1. Cohen, D. A. et al. Uncovering residual effects of chronic sleep loss on human performance. Sci. Transl. Med. 2, 14ra13 (2010). 2. Ohayon, M. M. From wakefulness to excessive sleepiness: what we know and still need to know. Sleep Med. Rev. 12, 129–141 (2008). 3. Slater, G. & Steier, J. Excessive daytime sleepiness in sleep disorders. J. Thorac. Dis. 4, 608–616 (2012). 4. Bixler, E. O. et al. Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J. Clin. Endocrinol. Metab. 90, 4510–4515 (2005). 5. Fernandez-Mendoza, J. et al. Natural history of excessive daytime sleepiness: role of obesity, weight loss, depression, and sleep propensity. Sleep 38, 351–360 (2015).
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