Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies-Reference-Cited by-同舟云学术

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Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

Published:2019-06-13 Issue:1 Volume:10 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Park Tae-Eun^ORCID,Mustafaoglu Nur,Herland Anna,Hasselkus Ryan^ORCID,Mannix Robert,FitzGerald Edward A.^ORCID,Prantil-Baun Rachelle,Watters Alexander,Henry Olivier,Benz Maximilian^ORCID,Sanchez Henry,McCrea Heather J.,Goumnerova Liliana Christova^ORCID,Song Hannah W.,Palecek Sean P.,Shusta Eric,Ingber Donald E.^ORCID

Funder

National Research Foundation of Korea

Knut och Alice Wallenbergs Stiftelse

United States Department of Defense | Defense Advanced Research Projects Agency

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-019-10588-0.pdf

Reference75 articles.

1. Cecchelli, R. et al. Modelling of the blood–brain barrier in drug discovery and development. Nat. Rev. Drug Discov. 6, 650–661 (2007).

2. Greene, C. & Campbell, M. Tight junction modulation of the blood brain barrier: CNS delivery of small molecules. Tissue Barriers 4, e1138017 (2016).

3. Mahringer, A., Ott, M., Reimold, I., Reichel, V. & Fricker, G. The ABC of the blood-brain barrier-regulation of drug efflux pumps. Curr. Pharm. Des. 17, 2762–2770 (2011).

4. Shawahna, R. et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol. Pharm. 8, 1332–1341 (2011).

5. Abbott, N. J. & Friedman, A. Overview and introduction: the blood-brain barrier in health and disease. Epilepsia 53, 1–6 (2012).

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