Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Author:

Song QiORCID,Yang YeORCID,Jiang DongxianORCID,Qin ZhaoyuORCID,Xu Chen,Wang Haixing,Huang Jie,Chen Lingli,Luo RongkuiORCID,Zhang Xiaolei,Huang Yufeng,Xu Lei,Yu ZixiangORCID,Tan SubeiORCID,Deng Minying,Xue Ruqun,Qie Jingbo,Li KaiORCID,Yin YananORCID,Yue XuetongORCID,Sun XiaogangORCID,Su Jieakesu,He Fuchu,Ding ChenORCID,Hou YingyongORCID

Abstract

AbstractSquamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal pathways and molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC characteristics, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a public resource for researchers seeking a better understanding of SCCs and ACs.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Xiamen Municipal Bureau of Science and Technology

Shanghai Science and Technology Development Foundation

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

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