Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

Author:

Stevens Brett M.,Khan Nabilah,D’Alessandro Angelo,Nemkov Travis,Winters Amanda,Jones Courtney L.,Zhang Wei,Pollyea Daniel A.ORCID,Jordan Craig T.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Reference70 articles.

1. Greenberg, P. L. et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood 120, 2454–2465 (2012).

2. de Witte, T. et al. Intensive chemotherapy for poor prognosis myelodysplasia (MDS) and secondary acute myeloid leukemia (sAML) following MDS of more than 6 months duration. A pilot study by the Leukemia Cooperative Group of the European Organisation for Research and Treatment in Cancer (EORTC-LCG). Leukemia 9, 1805–1811 (1995).

3. Ruutu, T. et al. Intensive chemotherapy of poor prognosis myelodysplastic syndromes (MDS) and acute myeloid leukemia following MDS with idarubicin and cytarabine. Leuk. Res. 21, 133–138 (1997).

4. Hope, K. J., Jin, L. & Dick, J. E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat. Immunol. 5, 738–743 (2004).

5. Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. NatMed 3, 730–737 (1997).

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