Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence-Reference-Cited by-同舟云学术

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Published:2019-05-29 Issue:1 Volume:10 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Sliepen Kwinten^ORCID,Han Byung Woo^ORCID,Bontjer Ilja,Mooij Petra,Garces Fernando,Behrens Anna-Janina,Rantalainen Kimmo,Kumar Sonu^ORCID,Sarkar Anita^ORCID,Brouwer Philip J. M.,Hua Yuanzi,Tolazzi Monica,Schermer Edith,Torres Jonathan L.^ORCID,Ozorowski Gabriel^ORCID,van der Woude Patricia,de la Peña Alba Torrents,van Breemen Mariëlle J.,Camacho-Sánchez Juan Miguel^ORCID,Burger Judith A.,Medina-Ramírez Max,González Nuria^ORCID,Alcami Jose,LaBranche Celia,Scarlatti Gabriella,van Gils Marit J.^ORCID,Crispin Max,Montefiori David C.,Ward Andrew B.^ORCID,Koopman Gerrit,Moore John P.^ORCID,Shattock Robin J.,Bogers Willy M.,Wilson Ian A.^ORCID,Sanders Rogier W.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-019-10262-5.pdf

Reference81 articles.

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2. Korber, B., Hraber, P., Wagh, K. & Hahn, B. H. Polyvalent vaccine approaches to combat HIV-1 diversity. Immunol. Rev. 275, 230–244 (2017).

3. Sanders, R. W. et al. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science 349, aac4223 (2015).

4. Sanders, R. W. et al. A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS Pathog. 9, e1003618 (2013).

5. Torrents de la Peña, A. et al. Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization. Cell Rep. 20, 1805–1817 (2017).

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