Plasmonic trimers designed as SERS-active chemical traps for subtyping of lung tumors

Author:

Zhao XingORCID,Liu Xiaojing,Chen DexiangORCID,Shi Guodong,Li GuoqunORCID,Tang XiaoORCID,Zhu Xiangnan,Li MingzeORCID,Yao LeiORCID,Wei Yunjia,Song WenzheORCID,Sun ZixuanORCID,Fan XingceORCID,Zhou Zhixin,Qiu TengORCID,Hao QiORCID

Abstract

AbstractPlasmonic materials can generate strong electromagnetic fields to boost the Raman scattering of surrounding molecules, known as surface-enhanced Raman scattering. However, these electromagnetic fields are heterogeneous, with only molecules located at the ‘hotspots’, which account for ≈ 1% of the surface area, experiencing efficient enhancement. Herein, we propose patterned plasmonic trimers, consisting of a pair of plasmonic dimers at the bilateral sides and a trap particle positioned in between, to address this challenge. The trimer configuration selectively directs probe molecules to the central traps where ‘hotspots’ are located through chemical affinity, ensuring a precise spatial overlap between the probes and the location of maximum field enhancement. We investigate the Raman enhancement of the Au@Al2O3-Au-Au@Al2O3 trimers, achieving a detection limit of 10−14 M of 4-methylbenzenethiol, 4-mercaptopyridine, and 4-aminothiophenol. Moreover, single-molecule SERS sensitivity is demonstrated by a bi-analyte method. Benefiting from this sensitivity, our approach is employed for the early detection of lung tumors using fresh tissues. Our findings suggest that this approach is sensitive to adenocarcinoma but not to squamous carcinoma or benign cases, offering insights into the differentiation between lung tumor subtypes.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

China Postdoctoral Science Foundation

Publisher

Springer Science and Business Media LLC

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