Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model-Reference-Cited by-同舟云学术

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

Published:2020-07-27 Issue:1 Volume:11 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Guttenplan Kevin A.^ORCID,Weigel Maya K.,Adler Drew I.,Couthouis Julien^ORCID,Liddelow Shane A.^ORCID,Gitler Aaron D.^ORCID,Barres Ben A.

Abstract

AbstractReactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1α, TNFα, and C1q, to induce neurotoxic astrocytes. Here we report that knocking out these three factors markedly extends survival in the SOD1G93A ALS mouse model, providing evidence for gliosis as a potential ALS therapeutic target.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-020-17514-9.pdf

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