Bidirectional propagation of low frequency oscillations over the human hippocampal surface

Author:

Kleen Jonathan K.ORCID,Chung Jason E.,Sellers Kristin K.ORCID,Zhou JennyORCID,Triplett MichaelORCID,Lee Kye,Tooker Angela,Haque RaziORCID,Chang Edward F.ORCID

Abstract

AbstractThe hippocampus is diversely interconnected with other brain systems along its axis. Cycles of theta-frequency activity are believed to propagate from the septal to temporal pole, yet it is unclear how this one-way route supports the flexible cognitive capacities of this structure. We leveraged novel thin-film microgrid arrays conformed to the human hippocampal surface to track neural activity two-dimensionally in vivo. All oscillation frequencies identified between 1–15 Hz propagated across the tissue. Moreover, they dynamically shifted between two roughly opposite directions oblique to the long axis. This predominant propagation axis was mirrored across participants, hemispheres, and consciousness states. Directionality was modulated in a participant who performed a behavioral task, and it could be predicted by wave amplitude topography over the hippocampal surface. Our results show that propagation directions may thus represent distinct meso-scale network computations, operating along versatile spatiotemporal processing routes across the hippocampal body.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke

United States Department of Defense | Defense Advanced Research Projects Agency

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

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