Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-019-10189-x.pdf
Reference58 articles.
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3. Brun, T. et al. Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets. Hum. Mol. Genet. 24, 5270–5284 (2015).
4. Göhring, I. et al. Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. J. Biol. Chem. 289, 3786–3798 (2014).
5. Fernandez, C. et al. Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13). J. Proteome Res. 7, 400–411 (2008).
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