Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells-Reference-Cited by-同舟云学术

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Published:2019-06-06 Issue:1 Volume:10 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Haythorne Elizabeth^ORCID,Rohm Maria^ORCID,van de Bunt Martijn,Brereton Melissa F.,Tarasov Andrei I.^ORCID,Blacker Thomas S.,Sachse Gregor^ORCID,Silva dos Santos Mariana^ORCID,Terron Exposito Raul,Davis Simon,Baba Otto,Fischer Roman^ORCID,Duchen Michael R.^ORCID,Rorsman Patrik^ORCID,MacRae James I.^ORCID,Ashcroft Frances M.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-019-10189-x.pdf

Reference58 articles.

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2. Ashcroft, F. M. & Rorsman, P. Diabetes and the beta-cell: the last ten years. Cell 148, 1160–1171 (2012).

3. Brun, T. et al. Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets. Hum. Mol. Genet. 24, 5270–5284 (2015).

4. Göhring, I. et al. Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. J. Biol. Chem. 289, 3786–3798 (2014).

5. Fernandez, C. et al. Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13). J. Proteome Res. 7, 400–411 (2008).

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