The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-017-01671-5.pdf
Reference49 articles.
1. Cragg, G. M. & Newman, D. J. Natural products: a continuing source of novel drug leads. Biochim. Biophys. Acta 1830, 3670–3695 (2013).
2. Jansen, R. et al. Carolacton-a macrolide ketocarbonic acid that reduces biofilm formation by the caries- and endocarditis-associated bacterium Streptococcus mutans. Eur. J. Org. Chem. 2010, 1284–1289 (2010).
3. Donner, J. et al. The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target. Sci. Rep. 6, 29677 (2016).
4. Kunze, B. et al. Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum. BMC Microbiol. 10, 199 (2010).
5. Green, J. M. & Matthews, R. G. Folate biosynthesis, reduction, and polyglutamylation and the interconversion of folate derivatives. EcoSal Plus 2, doi: 10.1128/ecosalplus.3.6.3.6 (2007).
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