Control of feeding by a bottom-up midbrain-subthalamic pathway

Author:

Reis Fernando M. C. V.,Maesta-Pereira SandraORCID,Ollivier Matthias,Schuette Peter J.,Sethi Ekayana,Miranda Blake A.,Iniguez Emily,Chakerian Meghmik,Vaughn Eric,Sehgal Megha,Nguyen Darren C. T.,Yuan Faith T. H.,Torossian Anita,Ikebara Juliane M.,Kihara Alexandre H.ORCID,Silva Alcino J.,Kao Jonathan C.,Khakh Baljit S.ORCID,Adhikari AvishekORCID

Abstract

AbstractInvestigative exploration and foraging leading to food consumption have vital importance, but are not well-understood. Since GABAergic inputs to the lateral and ventrolateral periaqueductal gray (l/vlPAG) control such behaviors, we dissected the role of vgat-expressing GABAergic l/vlPAG cells in exploration, foraging and hunting. Here, we show that in mice vgat l/vlPAG cells encode approach to food and consumption of both live prey and non-prey foods. The activity of these cells is necessary and sufficient for inducing food-seeking leading to subsequent consumption. Activation of vgat l/vlPAG cells produces exploratory foraging and compulsive eating without altering defensive behaviors. Moreover, l/vlPAG vgat cells are bidirectionally interconnected to several feeding, exploration and investigation nodes, including the zona incerta. Remarkably, the vgat l/vlPAG projection to the zona incerta bidirectionally controls approach towards food leading to consumption. These data indicate the PAG is not only a final downstream target of top-down exploration and foraging-related inputs, but that it also influences these behaviors through a bottom-up pathway.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Brain and Behavior Research Foundation

UC | UCLA | Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles

NSF | Directorate for Biological Sciences

Fundação de Amparo à Pesquisa do Estado de São Paulo

National Science Foundation

Publisher

Springer Science and Business Media LLC

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