GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
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Published:2018-12
Issue:1
Volume:9
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Franceschini Nora, , Giambartolomei ClaudiaORCID, de Vries Paul S., Finan Chris, Bis Joshua C., Huntley Rachael P.ORCID, Lovering Ruth C.ORCID, Tajuddin Salman M.ORCID, Winkler Thomas W.ORCID, Graff Misa, Kavousi Maryam, Dale Caroline, Smith Albert V., Hofer Edith, van Leeuwen Elisabeth M., Nolte Ilja M.ORCID, Lu Lingyi, Scholz MarkusORCID, Sargurupremraj Muralidharan, Pitkänen Niina, Franzén Oscar, Joshi Peter K.ORCID, Noordam Raymond, Marioni Riccardo E., Hwang Shih-Jen, Musani Solomon K., Schminke Ulf, Palmas Walter, Isaacs AaronORCID, Correa AdolfoORCID, Zonderman Alan B., Hofman Albert, Teumer AlexanderORCID, Cox Amanda J., Uitterlinden André G., Wong AndrewORCID, Smit Andries J., Newman Anne B.ORCID, Britton Annie, Ruusalepp Arno, Sennblad BengtORCID, Hedblad Bo, Pasaniuc Bogdan, Penninx Brenda W., Langefeld Carl D., Wassel Christina L., Tzourio Christophe, Fava Cristiano, Baldassarre DamianoORCID, O’Leary Daniel H., Teupser Daniel, Kuh DianaORCID, Tremoli Elena, Mannarino Elmo, Grossi Enzo, Boerwinkle Eric, Schadt Eric E.ORCID, Ingelsson Erik, Veglia Fabrizio, Rivadeneira FernandoORCID, Beutner Frank, Chauhan Ganesh, Heiss Gerardo, Snieder Harold, Campbell Harry, Völzke Henry, Markus Hugh S., Deary Ian J., Jukema J. WouterORCID, de Graaf Jacqueline, Price Jacqueline, Pott Janne, Hopewell Jemma C., Liang Jingjing, Thiery Joachim, Engmann Jorgen, Gertow Karl, Rice KennethORCID, Taylor Kent D., Dhana KlodianORCID, Kiemeney Lambertus A. L. M., Lind Lars, Raffield Laura M., Launer Lenore J., Holdt Lesca M., Dörr Marcus, Dichgans MartinORCID, Traylor MatthewORCID, Sitzer Matthias, Kumari Meena, Kivimaki MikaORCID, Nalls Mike A., Melander Olle, Raitakari Olli, Franco Oscar H., Rueda-Ochoa Oscar L., Roussos PanosORCID, Whincup Peter H., Amouyel PhilippeORCID, Giral Philippe, Anugu Pramod, Wong Quenna, Malik Rainer, Rauramaa Rainer, Burkhardt RalphORCID, Hardy Rebecca, Schmidt Reinhold, de Mutsert Renée, Morris Richard W.ORCID, Strawbridge Rona J., Wannamethee S. Goya, Hägg SaraORCID, Shah Sonia, McLachlan Stela, Trompet Stella, Seshadri Sudha, Kurl Sudhir, Heckbert Susan R., Ring Susan, Harris Tamara B., Lehtimäki Terho, Galesloot Tessel E., Shah Tina, de Faire Ulf, Plagnol Vincent, Rosamond Wayne D., Post Wendy, Zhu Xiaofeng, Zhang Xiaoling, Guo Xiuqing, Saba Yasaman, Dehghan Abbas, Seldenrijk Adrie, Morrison Alanna C., Hamsten Anders, Psaty Bruce M., van Duijn Cornelia M., Lawlor Deborah A.ORCID, Mook-Kanamori Dennis O., Bowden Donald W., Schmidt Helena, Wilson James F.ORCID, Wilson James G., Rotter Jerome I., Wardlaw Joanna M.ORCID, Deanfield John, Halcox Julian, Lyytikäinen Leo-PekkaORCID, Loeffler Markus, Evans Michele K., Debette Stéphanie, Humphries Steve E., Völker Uwe, Gudnason VilmundurORCID, Hingorani Aroon D., Björkegren Johan L. M., Casas Juan P., O’Donnell Christopher J.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference33 articles.
1. Mozaffarian, D. et al. Heart Disease and Stroke Statistics-2016 Update: a report from the American Heart Association. Circulation 133, e38–e360 (2016). 2. Frieden, T. R. & Berwick, D. M. The Million Hearts initiative--preventing heart attacks and strokes. N. Engl. J. Med. 365, e27 (2011). 3. O’Donnell, C. J. & Nabel, E. G. Genomics of cardiovascular disease. N. Engl. J. Med. 365, 2098–2109 (2011). 4. Bis, J. C. et al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat. Genet. 43, 940–947 (2011). 5. Natarajan, P. et al. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ. Cardiovasc. Genet. 9, 511–520 (2016).
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