Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
-
Published:2018-06-13
Issue:1
Volume:9
Page:
-
ISSN:2041-1723
-
Container-title:Nature Communications
-
language:en
-
Short-container-title:Nat Commun
Author:
Gusarova Viktoria, O’Dushlaine Colm, Teslovich Tanya M., Benotti Peter N., Mirshahi ToorajORCID, Gottesman Omri, Van Hout Cristopher V., Murray Michael F., Mahajan AnubhaORCID, Nielsen Jonas B.ORCID, Fritsche LarsORCID, Wulff Anders Berg, Gudbjartsson Daniel F.ORCID, Sjögren Marketa, Emdin Connor A.ORCID, Scott Robert A., Lee Wen-Jane, Small Aeron, Kwee Lydia C., Dwivedi Om Prakash, Prasad Rashmi B.ORCID, Bruse ShannonORCID, Lopez Alexander E., Penn John, Marcketta Anthony, Leader Joseph B.ORCID, Still Christopher D., Kirchner H. Lester, Mirshahi Uyenlinh L., Wardeh Amr H., Hartle Cassandra M., Habegger Lukas, Fetterolf Samantha N., Tusie-Luna Teresa, Morris Andrew P., Holm Hilma, Steinthorsdottir Valgerdur, Sulem PatrickORCID, Thorsteinsdottir Unnur, Rotter Jerome I., Chuang Lee-Ming, Damrauer Scott, Birtwell David, Brummett Chad M., Khera Amit V., Natarajan Pradeep, Orho-Melander Marju, Flannick Jason, Lotta Luca A., Willer Cristen J.ORCID, Holmen Oddgeir L., Ritchie Marylyn D.ORCID, Ledbetter David H.ORCID, Murphy Andrew J.ORCID, Borecki Ingrid B.ORCID, Reid Jeffrey G.ORCID, Overton John D., Hansson OlaORCID, Groop LeifORCID, Shah Svati H., Kraus William E., Rader Daniel J., Chen Yii-Der I., Hveem Kristian, Wareham Nicholas J., Kathiresan SekarORCID, Melander Olle, Stefansson Kari, Nordestgaard Børge G.ORCID, Tybjærg-Hansen Anne, Abecasis Goncalo R., Altshuler David, Florez Jose C., Boehnke Michael, McCarthy Mark I.ORCID, Yancopoulos George D., Carey David J., Shuldiner Alan R., Baras Aris, Dewey Frederick E., Gromada Jesper
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference58 articles.
1. Yoshida, K., Shimizugawa, T., Ono, M. & Furukawa, H. Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. J. Lipid Res. 43, 1770–1772 (2002). 2. Yau, M. H. et al. A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J. Biol. Chem. 284, 11942–11952 (2009). 3. Sukonina, V., Lookene, A., Olivecrona, T. & Olivecrona, G. Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc. Natl. Acad. Sci. USA 103, 17450–17455 (2006). 4. Koster, A. et al. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology 146, 4943–4950 (2005). 5. Romeo, S. et al. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat. Genet. 39, 513–516 (2007).
Cited by
109 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|