Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-019-08691-3.pdf
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3. Frandberg, P. A., Doufexis, M., Kapas, S. & Chhajlani, V. Human pigmentation phenotype: a point mutation generates nonfunctional MSH receptor. Biochem. Biophys. Res. Commun. 245, 490–492 (1998).
4. Wong, T. H. & Rees, J. L. The relation between melanocortin 1 receptor (MC1R) variation and the generation of phenotypic diversity in the cutaneous response to ultraviolet radiation. Peptides 26, 1965–1971 (2005).
5. Valverde, P., Healy, E., Jackson, I., Rees, J. L. & Thody, A. J. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat. Genet. 11, 328–330 (1995).
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