Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
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Published:2018-09-26
Issue:1
Volume:9
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Vojinovic Dina, Adams Hieab H.ORCID, Jian Xueqiu, Yang QiongORCID, Smith Albert VernonORCID, Bis Joshua C., Teumer AlexanderORCID, Scholz MarkusORCID, Armstrong Nicola J., Hofer Edith, Saba Yasaman, Luciano MichelleORCID, Bernard Manon, Trompet Stella, Yang Jingyun, Gillespie Nathan A., van der Lee Sven J.ORCID, Neumann AlexanderORCID, Ahmad Shahzad, Andreassen Ole A.ORCID, Ames David, Amin Najaf, Arfanakis Konstantinos, Bastin Mark E., Becker Diane M., Beiser Alexa S., Beyer Frauke, Brodaty HenryORCID, Bryan R. Nick, Bülow Robin, Dale Anders M., De Jager Philip L.ORCID, Deary Ian J., DeCarli Charles, Fleischman Debra A., Gottesman Rebecca F., van der Grond Jeroen, Gudnason VilmundurORCID, Harris Tamara B., Homuth Georg, Knopman David S., Kwok John B., Lewis Cora E., Li ShuoORCID, Loeffler Markus, Lopez Oscar L., Maillard Pauline, El Marroun Hanan, Mather Karen A., Mosley Thomas H., Muetzel Ryan L., Nauck Matthias, Nyquist Paul A., Panizzon Matthew S., Pausova Zdenka, Psaty Bruce M., Rice Ken, Rotter Jerome I., Royle Natalie, Satizabal Claudia L.ORCID, Schmidt Reinhold, Schofield Peter R.ORCID, Schreiner Pamela J., Sidney Stephen, Stott David J., Thalamuthu Anbupalam, Uitterlinden Andre G., Valdés Hernández Maria C., Vernooij Meike W., Wen Wei, White Tonya, Witte A. Veronica, Wittfeld Katharina, Wright Margaret J.ORCID, Yanek Lisa R., Tiemeier HenningORCID, Kremen William S., Bennett David A., Jukema J. Wouter, Paus Tomas, Wardlaw Joanna M.ORCID, Schmidt Helena, Sachdev Perminder S.ORCID, Villringer Arno, Grabe Hans JörgenORCID, Longstreth W T, van Duijn Cornelia M., Launer Lenore J., Seshadri Sudha, Ikram M ArfanORCID, Fornage Myriam
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference72 articles.
1. Pfefferbaum, A., Sullivan, E. V. & Carmelli, D. Morphological changes in aging brain structures are differentially affected by time-linked environmental influences despite strong genetic stability. Neurobiol. Aging 25, 175–183 (2004). 2. Carmichael, O. T. et al. Ventricular volume and dementia progression in the Cardiovascular Health Study. Neurobiol. Aging 28, 389–397 (2007). 3. Apostolova, L. G. et al. Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease. Alzheimer Dis. Assoc. Disord. 26, 17–27 (2012). 4. Long, X. et al. Healthy aging: an automatic analysis of global and regional morphological alterations of human brain. Acad. Radiol. 19, 785–793 (2012). 5. Nestor, S. M. et al. Ventricular enlargement as a possible measure of Alzheimer’s disease progression validated using the Alzheimer’s disease neuroimaging initiative database. Brain 131, 2443–2454 (2008).
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