Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-04061-7.pdf
Reference29 articles.
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3. Alley, W. R. Jr., Mann, B. F. & Novotny, M. V. High-sensitivity analytical approaches for the structural characterization of glycoproteins. Chem. Rev. 113, 2668–2732 (2013).
4. Siuti, N. & Kelleher, N. L. Decoding protein modifications using top-down mass spectrometry. Nat. Methods 4, 817–821 (2007).
5. Beck, A., Wagner-Rousset, E., Ayoub, D., Van Dorsselaer, A. & Sanglier-Cianferani, S. Characterization of therapeutic antibodies and related products. Anal. Chem. 85, 715–736 (2013).
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