Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Author:

Peña Catherine JensenORCID,Smith Milo,Ramakrishnan Aarthi,Cates Hannah M.ORCID,Bagot Rosemary C.,Kronman Hope G.,Patel Bhakti,Chang Austin B.,Purushothaman Immanuel,Dudley Joel,Morishita HirofumiORCID,Shen LiORCID,Nestler Eric J.ORCID

Abstract

Abstract Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice, consistent with our earlier findings in male mice. We used RNA-sequencing in the ventral tegmental area, nucleus accumbens, and prefrontal cortex of male and female mice to show that adult stress is distinctly represented in the brain’s transcriptome depending on ELS history. We identify: 1) biological pathways disrupted after ELS and associated with increased behavioral stress sensitivity, 2) putative transcriptional regulators of the effect of ELS on adult stress response, and 3) subsets of primed genes specifically associated with latent behavioral changes. We also provide transcriptomic evidence that ELS increases sensitivity to future stress through enhancement of known programs of cortical plasticity.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health

Hope for Depression Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

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