The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function
Author:
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Link
http://www.nature.com/articles/ni.2938.pdf
Reference84 articles.
1. Hogquist, K.A., Baldwin, T.A. & Jameson, S.C. Central tolerance: learning self-control in the thymus. Nat. Rev. Immunol. 5, 772–782 (2005).
2. Stritesky, G.L. et al. Murine thymic selection quantified using a unique method to capture deleted T cells. Proc. Natl. Acad. Sci. USA 110, 4679–4684 (2013).
3. Daley, S.R., Hu, D.Y. & Goodnow, C.C. Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J. Exp. Med. 210, 269–285 (2013).This study reports that helios expression distinguishes cells undergoing positive and negative selection in the thymus. Analogously to the previous study, they analyzed helios expression in Bim deficient mice to define the extent of clonal deletion.
4. Sinclair, C., Bains, I., Yates, A.J. & Seddon, B. Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc. Natl. Acad. Sci. USA 110, E2905–E2914 (2013).Sinclair et al . estimate rates of death and differentiation using mathematical analysis of synchronized cohorts of thymocytes developing in an inducible ZAP70 model. Their results suggest an asymmetry in the death rates of class I– and class II–restricted thymocytes, and concur remarkably well with the previous two studies that the majority of cells that start selection fail to complete it.
5. Garcia, K.C. et al. A closer look at TCR germline recognition. Immunity 36, 887–888, author reply 889–890 (2012).
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