Genotype to phenotype: lessons from model organisms for human genetics
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3404.pdf
Reference109 articles.
1. Hindorff, L. A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA 106, 9362–9367 (2009).
2. Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747–753 (2009).
3. Burga, A. & Lehner, B. Beyond genotype to phenotype: why the phenotype of an individual cannot always be predicted from their genome sequence and the environment that they experience. FEBS J. 279, 3765–3775 (2012).
4. Clayton, D. G. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet. 5, e1000540 (2009).
5. Roberts, N. J. et al. The predictive capacity of personal genome sequencing. Sci. Transl. Med. 4, 133ra58 (2012). This study provides estimates of the maximum ability of whole-genome sequencing to predict clinically useful risk information for 24 diseases on the basis of analyses of monzygotic twin pairs.
Cited by 189 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Long-read sequencing-based transcriptomic landscape in longissimus dorsi and transcriptome-wide association studies for growth traits of meat rabbits;Frontiers in Veterinary Science;2024-01-22
2. DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype–phenotype prediction;Genome Medicine;2023-10-31
3. Deep learning for optimization of protein expression;Current Opinion in Biotechnology;2023-06
4. Secure Inference on Homomorphically Encrypted Genotype Data with Encrypted Linear Models;2023-04-03
5. Use of Arabidopsis thaliana as a model to understand specific carcinogenic events: Comparison of the molecular machinery associated with cancer-hallmarks in plants and humans;Heliyon;2023-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3