Targeting TAK1 in microglia to treat CAR T cell neurotoxicity
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s43018-024-00765-6.pdf
Reference5 articles.
1. Santomasso, B. D. et al. Clinical and biological correlates of neurotoxicity associated with CAR T-cell therapy in patients with B-cell acute lymphoblastic leukemia. Cancer Discov. 8, 958–971 (2018). This article reports the risk factors associated with neurotoxicity in patients after transfer of CD19 CAR T cells.
2. Lee, D. W. et al. ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells, biology of blood and marrow transplantation. Biol. Blood Marrow Transplant. 25, 625–638 (2019). This paper reports on the consensus-grading scheme for cytokine-release syndrome and neurotoxicity associated with CAR T cell therapy.
3. Maus, M. V. et al. Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events. J. Immunother. Cancer 2, e001511 (2020). This article provides guidance on pharmacological interventions and management of toxicities associated with immune cell effector therapies.
4. Strati, P. et al. Prognostic impact of corticosteroids on efficacy of chimeric antigen receptor T-cell therapy in large B-cell lymphoma. Blood 137, 3272–3276 (2021). This article reports a negative impact of corticosteroid treatment on progression-free survival of patients receiving anti-CD19 CAR T cells for large B cell lymphoma.
5. Mathew, N. R. & Vinnakota, J. M. et al. Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. J. Clin. Invest. 130, 1315–1329 (2020). This paper reports a role for microglia in the pathogenesis of graft-versus-host disease of the central nervous system.
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