A roadmap of therapeutic strategies for patients with multiple myeloma
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology
Link
https://www.nature.com/articles/s43018-023-00545-8.pdf
Reference5 articles.
1. Severin, Y. et al. Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypes. Sci. Adv. 8, eabn5631 (2022). In this previous study from our group, we used PCY and deep learning to study immune cell morphology.
2. Shilts, J. et al. A physical wiring diagram for the human immune system. Nature 608, 397–404 (2022). This study used protein–protein interaction mapping and PCY to uncover regulators of immune cell interactions.
3. Snijder, B. et al. Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study. Lancet Haematol. 4, e595–e606 (2017). This study provided the first evidence that PCY identifies effective treatments for patients with blood cancer.
4. Kornauth, C. et al. Functional precision medicine provides clinical benefit in advanced aggressive hematologic cancers and identifies exceptional responders. Cancer Discov. 12, 372–387 (2022). The final analysis of this clinical study confirmed PCY-driven benefits for the treatment of blood cancers.
5. Lee, S. et al., Targeting tumour-intrinsic neural vulnerabilities of glioblastoma. Preprint at bioRxiv https://doi.org/10.1101/2022.10.07.511321 (2022). This preprint study using PCY on brain tumors revealed drug-repurposing candidates and associated mechanisms.
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1. Biomimetic cell membrane decorated ZIF‐8 nanocarriers with IR‐780 and doxorubicin loading for multiple myeloma treatment;Aggregate;2024-07-02
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