Towards accurate genomics for newly diagnosed metastatic prostate cancer

Author:

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference5 articles.

1. Helgstrand, J. T. et al. Trends in incidence and 5-year mortality in men with newly diagnosed, metastatic prostate cancer-A population-based analysis of 2 national cohorts. Cancer 124, 2931–2938 (2018). This paper describes the survival of individuals with de novo metastatic prostate cancer from two cohorts in the USA and Denmark.

2. Espiritu, S. M. G. et al. The evolutionary landscape of localized prostate cancers drives clinical aggression. Cell 173, 1003–1013.e15 (2018). This study reports that heterogeneity within localized prostate cancers is associated with poor prognosis. It uses samples obtained from radical surgery, which are commonly available in the localized setting.

3. Mateo, J. et al. Genomics of lethal prostate cancer at diagnosis and castration resistance. J. Clin. Invest. 130, 1743–1751 (2020). This paper reports on the genomic landscape of metastatic prostate cancer and tracks cancer evolution from a single biopsy at diagnosis to a biopsy at treatment resistance.

4. Stopsack, K. H. et al. oncogenic genomic alterations, clinical phenotypes, and outcomes in metastatic castration-sensitive prostate cancer. Clin. Cancer Res. 26, 3230–3238 (2020). This paper reports the common genomic alterations and corresponding clinical correlates in metastatic castration-sensitive prostate cancer using a single biopsy sample.

5. Sathianathen, N. J. et al. Emergence of triplet therapy for metastatic castration-sensitive prostate cancer: an updated systematic review and network meta-analysis. Urologic Oncol. 41, 233–239 (2023). A review article presenting the treatment landscape of metastatic prostate cancer.

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