A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy-Reference-Cited by-同舟云学术

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A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy

Published:2020-03 Issue:3 Volume:1 Page:315-328
ISSN:2662-1347
Container-title:Nature Cancer
language:en
Short-container-title:Nat Cancer

Author:

Amgalan Dulguun^ORCID,Garner Thomas P.,Pekson Ryan,Jia Xiaotong F.,Yanamandala Mounica,Paulino Victor,Liang Felix G.,Corbalan J. Jose,Lee Jaehoon,Chen Yun,Karagiannis George S.,Sanchez Luis Rivera,Liang Huizhi,Narayanagari Swathi-Rao,Mitchell Kelly^ORCID,Lopez Andrea,Margulets Victoria,Scarlata Marco,Santulli Gaetano^ORCID,Asnani Aarti,Peterson Randall T.,Hazan Rachel B.,Condeelis John S.^ORCID,Oktay Maja H.,Steidl Ulrich^ORCID,Kirshenbaum Lorrie A.,Gavathiotis Evripidis^ORCID,Kitsis Richard N.^ORCID

Funder

American Heart Association

U.S. Department of Health & Human Services | NIH | National Cancer Institute

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

John S. LaDue Memorial Fellowship at Harvard Medical School

Breast Cancer Research Foundation

Canadian Institutes for Health Research Foundation Grant

Fondation Leducq

U.S. Department of Defense

Harrington Scholar-Innovator Award

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

http://www.nature.com/articles/s43018-020-0039-1.pdf

Reference64 articles.

1. Moslehi, J. J. Cardiovascular toxic effects of targeted cancer therapies. N. Engl. J. Med. 375, 1457–1467 (2016).

2. Moslehi, J., Amgalan, D. & Kitsis, R. N. Grounding cardio-oncology in basic and clinical science. Circulation 136, 3–5 (2017).

3. Middleman, E., Luce, J. & Frei, E. 3rd Clinical trials with adriamycin. Cancer 28, 844–850 (1971).

4. Lefrak, E. A., Pitha, J., Rosenheim, S. & Gottlieb, J. A. A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32, 302–314 (1973).

5. Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D. & Liu, L. F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 226, 466–468 (1984).

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