Telomerase inhibitor imetelstat kills AML cells via lipid ROS and ferroptosis
Author:
Funder
Department of Health | National Health and Medical Research Council
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s43018-023-00654-4.pdf
Reference5 articles.
1. Tefferi, A. et al. A pilot study of the telomerase inhibitor imetelstat for myelofibrosis. N. Engl. J. Med. 373, 908–919 (2015). This paper reports clinical efficacy of imetelstat in patients with myelofibrosis.
2. Steensma, D. P. et al. Imetelstat achieves meaningful and durable transfusion independence in high transfusion-burden patients with lower-risk myelodysplastic syndromes in a phase ii study. J. Clin. Oncol. 39, 48–56 (2021). This paper reports clinical responses of imetelstat in high transfusion-burden patients with MDS.
3. Herbert, B. S. et al. Lipid modification of GRN163, an N3'->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene. 24, 5262–5268 (2005). This paper describes the structure of imetelstat.
4. Waksal, J. A. et al. Telomerase-targeted therapies in myeloid malignancies. Blood Adv. https://doi.org/10.1182/bloodadvances.2023009903 (2023). A review that presents an overview of telomerase-targeted therapies in blood cancers.
5. Jiang, X. et al. Ferroptosis: mechanisms, biology and role in disease. Nat. Rev. Mol. Cell Biol. 22, 266–282 (2021). A review that highlights mechanisms of ferroptosis in disease.
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