The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer-Reference-Cited by-同舟云学术

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The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Published:2021-11-11 Issue:12 Volume:2 Page:1357-1371
ISSN:2662-1347
Container-title:Nature Cancer
language:en
Short-container-title:Nat Cancer

Author:

Adam Salomé,Rossi Silvia Emma,Moatti Nathalie,De Marco Zompit Mara,Xue Yibo^ORCID,Ng Timothy F.,Álvarez-Quilón Alejandro,Desjardins Jessica,Bhaskaran Vivek,Martino Giovanni,Setiaputra Dheva,Noordermeer Sylvie M.^ORCID,Ohsumi Toshiro K.,Hustedt Nicole,Szilard Rachel K.,Chaudhary Natasha,Munro Meagan,Veloso Artur,Melo Henrique,Yin Shou Yun,Papp Robert,Young Jordan T. F.,Zinda Michael,Stucki Manuel,Durocher Daniel^ORCID

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Groeber Foundation

Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre

Krembil Foundation

Canadian Cancer Society Research Institute

Repare Therapeutics

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

https://www.nature.com/articles/s43018-021-00266-w.pdf

Reference60 articles.

1. Roy, R., Chun, J. & Powell, S. N. BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat. Rev. Cancer 12, 68–78 (2011).

2. Moynahan, M. E. & Jasin, M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat. Rev. Mol. Cell Biol. 11, 196–207 (2010).

3. Nik-Zainal, S. et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature 534, 47–54 (2016).

4. Setton, J. et al. Synthetic lethality in cancer therapeutics: the next generation. Cancer Discov. https://doi.org/10.1158/2159-8290.CD-20-1503 (2021).

5. Lord, C. J. & Ashworth, A. PARP inhibitors: synthetic lethality in the clinic. Science 355, 1152–1158 (2017).

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