Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome-Reference-Cited by-同舟云学术

Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome

Published:2022-04-14 Issue:5 Volume:3 Page:629-648
ISSN:2662-1347
Container-title:Nature Cancer
language:en
Short-container-title:Nat Cancer

Author:

Golbourn Brian J.,Halbert Matthew E.,Halligan Katharine,Varadharajan Srinidhi^ORCID,Krug Brian,Mbah Nneka E.,Kabir Nisha,Stanton Ann-Catherine J.,Locke Abigail L.,Casillo Stephanie M.,Zhao Yanhua,Sanders Lauren M.,Cheney Allison^ORCID,Mullett Steven J.,Chen Apeng^ORCID,Wassell Michelle,Andren Anthony,Perez Jennifer,Jane Esther P.,Premkumar Daniel R. David,Koncar Robert F.^ORCID,Mirhadi Shideh,McCarl Lauren H.,Chang Yue-Fang,Wu Yijen L.,Gatesman Taylor A.,Cruz Andrea F.,Zapotocky Michal^ORCID,Hu Baoli,Kohanbash Gary,Wang Xiuxing^ORCID,Vartanian Alenoush,Moran Michael F.,Lieberman Frank,Amankulor Nduka M.,Wendell Stacy G.,Vaske Olena M.,Panigrahy Ashok,Felker James,Bertrand Kelsey C.,Kleinman Claudia L.^ORCID,Rich Jeremy N.,Friedlander Robert M.,Broniscer Alberto,Lyssiotis Costas^ORCID,Jabado Nada^ORCID,Pollack Ian F.,Mack Stephen C.^ORCID,Agnihotri Sameer^ORCID

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

https://www.nature.com/articles/s43018-022-00348-3.pdf

Reference70 articles.

1. Louis, D. N. et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro-oncology https://doi.org/10.1093/neuonc/noab106 (2021).

2. Hoffman, L. M. et al. Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries. J. Clin. Oncol. 36, 1963–1972 (2018).